A Pseudohermaphrodite with Suprarenal Cortical Hyperplasia

A male pseudohermaphrodite with a dicentric Y chromosome. Autoradiographic study.

A 13-year-old male pseudohermaphrodite (mixed gonadal dysgenesis, unilateral testicular differentiation) was found to be a chromosomal mosaic of the 45, X0/46, XY type, the Y chromosome being a symmetrical dicentric chromosome. Presumed ¥ chromosomes similar to this one have been observed before, but their identification was not supported by autoradiographic data. In the present study the ident...

Two cases of adrenal hyperplasia with adrenal cortical insufficiency.

The adreno-genital syndrome in infancy is associated almost invariably with bilateral adrenal hyperplasia. The characteristic syndrome is a combination of hyperfunction of the genital hormones of the suprarenal, producing precocious virilism in males and pseudohermaphroditism in females, and hypofunction of the salt-water hormones resulting in an electrolyte imbalance of the Addisonian type. Gl...

Adrenal Cortical Hyperplasia with Virilism: Diagnosis, Course and Treatment.

Suprarenal Tumors

maffin cells of the medulla, on the other hand, are derived from primitive mural elements having an origin in common with other components of the sympathetic nervous system. The pathologic behavior of the tumors emphasizes this two-fold origin (Fig. 1). The more rapidly growing cortical tumors are accompanied by changes in the sex characteristics of the patient, while the medullary tumors show ...

Suprarenal Virilism

Until a year ago the patient, a girl aged 5 years, was to all appearances norma], mentally and physically. During the dst twelve months she became fat, listless, unusually silent, Prone to sit about, disinclined to take an interest in her Surroundings or to play with other children. With the increasing fatness growth in stature was at an normally vigorous rate, hair developing on the limbs and ...